Would it be possible to suggest the answer to "The meaning of life" to be 42?
and perhaps some other pop-culture jokes?
other examples that spring to mind...
Q "Thats one small step for man" A "and one giant line for admission" - Futurama
Q "Speed of a sparrow" A "European or African?" - Monty Python
Q "Favourite color?" A "Blue no, yellow!!!!!", then maybe put a 304 or something - Monty Python
Q "I have a headache" A "Its not a TOOMA!" - Kindergarten Cop
Q "Once you pop" A "You cant stop!" - Push pup ads
people might even be able to suggest silly answers... although i think thats its own site now :)
or maybe steal some of these rap related graph jokes...
http://www.jamphat.com/rap/